Comparative Evaluation of Gemcabene and Peroxisome Proliferator–Activated Receptor Ligands in Transcriptional Assays of Peroxisome Proliferator–Activated Receptors
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چکیده
منابع مشابه
Cannabinoid activation of peroxisome proliferatoractivated receptors: an update and review of the physiological relevance
Since 2002, evidence has been building that cannabinoids, including endocannabinoids and endocannabinoid-like compounds, phytocannabinoids and synthetic cannabinoid ligands, bind to and activate the different isoforms of the nuclear receptors, peroxisome proliferator-activated receptors (PPARs; α, β, and γ ). This has been shown through the use of reporter gene assays, binding studies, the use ...
متن کاملPeroxisome proliferatoractivated receptor g is essential for secretion of ANP induced by prostaglandin D2 in the beating rat atrium
Author contributions: Z.Y. and L.X. performed atrial perfused experiments. L.L.P and H.L. performed WB analysis. L.X. and Z.B. performed ANP measurement. W.C.Z. and C.X. designed experiments and wrote the manuscript. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, ...
متن کاملRole of peroxisome proliferator-activated receptor alpha and gamma in antiangiogenic effect of pomegranate peel extract
Objective(s): Herbal medicines are promising cancer preventive candidates. It has been shown that Punica granatum L. could inhibit angiogenesis and tumor invasion. In this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (PPE) is partly attributable to Peroxisome proliferator-activated receptors (PPARs) activation in the Human Umbilical Vein Endothelial Cell...
متن کاملThe toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).
Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Ligands for the PPARs have been widely developed for the treatment of various diseases including dyslipidemias and diabetes. While targeting selective receptor activation is an established therapeutic approach for th...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 2018
ISSN: 0160-2446
DOI: 10.1097/fjc.0000000000000580